Placental disorders in displaced pregnant women who are in persistent stress

Objectives: to determine morphological and immunohistochemical changes in the placentas of displaced pregnant women order further improve antenatal monitoring program.Materials methods. 96 (the main group) took part prospective study, who depending on therapy were divided into: group I – 65 monitored according generally accepted recommendations received routine for prolonging pregnancy, II 31 proposed treatment prophylactic complex (micronized progesterone, magnesium citrate combination with pyridoxine hydrochloride, iron fumarate, a multivitamin 200 mg docosahexaenoic acid, medical psychological support women). The control consisted 39 living at territories controlled by Ukraine. duration observation was 2 years. Placentas examined organometric, macroscopic, general histological methods.Results. Organometrically, had significant decrease thickness, mass size. Edema Wharton jelly significantly more pronounced this group, lumen vessels there parietal formation fibrin blood clots. Manifestations ischemic infarcts clots, which located mainly paracentral peripheral zones, found frequently among I. Histologically, tissue noted I, are manifestations placental damage characterized partial maternal-fetal-placental perfusion. These combined focal edema decidual dystrophy cells. In an uneven focal, sometimes proliferation syncytial nodules widespread nature noted, is marker cellular aging associated adverse factors affecting mother’s body. Also, foci maternal perfusion barrier.Immunohistochemically, vacuolization chromatin arrangement observed nuclei villi cells during Ki-67 immersion, indicated regenerative responses barrier groups II, especially elevated cortisol levels. Immunohistochemical studies pro-apoptotic P-53 showed expression single stroma cells.Conclusions. detected structures indicate predominance disorders compared groups, syncytium villi, led violation placenta functioning. Morphological confirmed impact long-term chronic stress functioning uterine-placental-fetal complex, as well effectiveness preventing identified disorders.